Comprehensive Product Description: Aminoxin Injection / Capsules (Pyridoxine Hydrochloride, Vitamin B₆)

Aminoxin (pyridoxine hydrochloride, or Vitamin B₆) is used to treat and prevent Vitamin B₆ deficiency conditions, including neuropathy induced by isoniazid therapy or other causes, sideroblastic anemia, and certain metabolic or neurologic disorders.

Aminoxin (Pyridoxine Hydrochloride) – Available as oral tablets, extended‑release capsules, solution, and injectable formulations

Pyridoxine Hydrochloride (Vitamin B₆)

Other Popular and Common Names:
Vitabee 6, Pyri‑500, Rodex

Pyridoxal phosphate precursor

Vitamin B₆ supplement

Pyridoxine Injection or oral syrup

Pyridoxine is converted in the liver to pyridoxal‑5'‑phosphate (PLP), the active coenzyme form of Vitamin B₆. PLP is critical in:

Amino acid, carbohydrate, and lipid metabolism

Neurotransmitter synthesis (GABA, dopamine, serotonin)

Hemoglobin formation and heme synthesis

Immune function, lymphocyte proliferation, and interleukin‑2 production

Aminoxin is indicated for:

Vitamin B₆ deficiency due to poor intake, malabsorption, alcoholism, or chronic illness

Prevention and treatment of isoniazid‑induced neuropathy

Hydralazine‑ or cycloserine‑induced peripheral neuropathy

Pyridoxine‑responsive anemia (e.g., sideroblastic anemia)

Treatment of certain convulsions or seizures in infants or children when related to B₆ deficiency
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Oral (Adults):
Prophylactic dose: 2–5 mg daily

Therapeutic dose: 10–50 mg daily; up to 100 mg/day in deficiency states or drug‑induced neuropathy

Pediatric:
Weight-based dosing per physician orders in infants or children

Injectable (Under medical supervision):
100–300 mg intramuscular or intravenous, especially when oral route is not feasible (e.g., vomiting, malabsorption)
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Administration Notes:

Oral preparations may be extended‑release capsules—swallow whole without crushing

Injectable form to be administered only by qualified healthcare professionals

Formulations: Oral tablet, ER capsule, syrup/solution, Injection vial

Strengths: 10 mg, 50 mg, 100 mg per dose forms

Storage: Store at 20–25 °C, away from moisture and direct sunlight. Keep out of reach of children

Availability: OTC for standard dose; prescription may be required in injectable or higher‑dose forms

Safety Information & Contraindications:
Contraindicated in known hypersensitivity to pyridoxine or excipients

Use with caution in renal insufficiency or for prolonged high-dose therapy

Not appropriate as monotherapy for other forms of anemia or seizures without underlying B₆ deficiency

Common (with therapeutic doses):
Normally well tolerated; minimal adverse reactions

Transient gastrointestinal symptoms (nausea, abdominal discomfort)

Associated with high-dose or long‑term use:
Neuropathy, numbness, tingling, or ataxia—may be irreversible if prolonged

Headache, somnolence
Allergic reactions: rash, itching, swelling, anaphylaxis (very rare)

Warnings & Precautions:
Monitor for sensory neuropathy if high-dose B₆ is used long‑term

Avoid use with levodopa alone, as pyridoxine enhances peripheral dopamine formation reducing central efficacy—co‑administration with a decarboxylase inhibitor is required
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Alert if on oral contraceptives, isoniazid, cycloserine, or hydralazine, as these drugs deplete Vitamin B₆ stores and may require supplementation

Therapeutic Class: Nutritional medicine, Vitamin supplement

Pharmacological Class: Water‑soluble Vitamin B₆ (pyridoxine)

ATC Code: A11HA02

Drug Interactions (Clinically Supported):
Isoniazid, hydralazine, cycloserine: Increase requirement for pyridoxine; deficiency common without supplementation

Levodopa: Pyridoxine increases peripheral dopamine, reducing central therapeutic effect unless given with a decarboxylase inhibitor

Phenobarbital, phenytoin, oral contraceptives: May lower Vitamin B₆ levels, necessitating supplementation
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Generally safe in pregnancy and lactation when used at recommended doses; passes into breast milk in small amounts, considered low risk
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FAQs – Frequently Asked Questions
Q: What is Aminoxin used to treat?
A: Aminoxin is used to prevent and treat Vitamin B₆ deficiency, manage isoniazid-induced neuropathy, and certain types of anemia or metabolic convulsions related to B₆ deficiency.

Q: How long before deficiency symptoms improve?
A: Improvement in neuropathy or hematologic parameters is often observed within 2–6 weeks of regular supplementation.

Q: Can I stop therapy once symptoms improve?
A: In drug-induced deficiency, supplementation should continue for the full duration of offending drug therapy. Consult your doctor before stopping.

Q: Is long-term use safe?
A: Low-dose daily use is generally safe. Prolonged high-dose therapy (>200 mg/day) may lead to sensory neuropathy.

Q: Can Aminoxin be given intravenously?
A: Yes, injectable pyridoxine is used under medical supervision when oral administration isn’t feasible, such as in patients with vomiting or malabsorption.