Comprehensive Product Description for Amaryl (Glimepiride)

Amaryl (Glimepiride) is a once-daily oral antidiabetic medication used to control blood sugar levels in adults with type 2 diabetes mellitus. It works by stimulating insulin release from pancreatic beta cells and improving insulin sensitivity. Available online at EZ Chemist.

Amaryl Tablets

Glimepiride

Glimepiride Tablets

Glimepiride Oral Hypoglycemic Agent

Amaryl 1 mg, Amaryl 2 mg, Amaryl 4 mg

Sulfonylurea Antidiabetic Agent

Glimepiride

Therapeutic Class: Antidiabetic

Pharmacologic Class: Sulfonylurea

Schedule: Prescription Only (Rx)

ATC Code: A10BB12

Glimepiride lowers blood glucose levels through a dual mechanism:

Stimulates insulin release from functioning pancreatic beta cells by blocking ATP-sensitive potassium channels.

Enhances peripheral insulin sensitivity, improving glucose uptake and utilization by muscle and adipose tissue.

This makes it particularly useful for managing type 2 diabetes mellitus in non-insulin-dependent adults.

Amaryl is indicated for:

Type 2 Diabetes Mellitus in adults when diet, exercise, and weight reduction alone are insufficient

May be used as monotherapy or in combination with:

Metformin

Thiazolidinediones (e.g., pioglitazone)

Insulin

Recommended Dosage:
Initial Dose: 1 mg once daily with breakfast or the first main meal

Maintenance Dose: 1–4 mg/day, may be titrated up to 8 mg/day

Maximum Dose: 8 mg once daily

Titrate dosage based on patient’s fasting blood glucose and tolerance. Always use the lowest effective dose to minimize hypoglycemia risk.

Take with food to reduce the risk of low blood sugar

Do not skip meals when on glimepiride

Avoid alcohol as it may mask or exaggerate hypoglycemia

Monitor blood glucose and HbA1c regularly

Adjust dosage in cases of renal or hepatic impairment

Patient should receive dietary and exercise counseling

Contraindications:
Known hypersensitivity to glimepiride, other sulfonylureas, or sulfonamides

Type 1 diabetes mellitus

Diabetic ketoacidosis with or without coma

Severe renal or hepatic insufficiency

Pregnancy and lactation (unless advised by physician)

Hypoglycemia (sweating, tremor, dizziness, hunger)

Headache

Nausea

Weight gain

Allergic skin reactions (rash, itching)

Visual disturbances (transient)

Severe hypoglycemia requiring medical attention

Hemolytic anemia (especially in G6PD deficiency)

Hepatic dysfunction or jaundice

Stevens-Johnson syndrome

Photosensitivity reactions

Hypoglycemia Risk: Greater in elderly, malnourished, or renal-impaired patients

Use cautiously in those with liver disease, adrenal or pituitary insufficiency

Renal or hepatic function should be monitored before and during therapy

Not recommended during pregnancy or breastfeeding—insulin is preferred

Avoid during periods of acute illness, surgery, or stress

Potentiating Hypoglycemic Effects:
NSAIDs (e.g., ibuprofen)

MAO inhibitors

Beta-blockers

ACE inhibitors

Alcohol

Insulin and other antidiabetics

Reducing Hypoglycemic Effects:
Thiazides

Corticosteroids

Oral contraceptives

Sympathomimetics

Thyroid hormones

Rifampicin

Phenytoin

A randomized, double-blind study published in Diabetes Care demonstrated that glimepiride was effective in lowering HbA1c by up to 1.5–2%, with a lower incidence of severe hypoglycemia compared to glyburide.

Combination therapy with metformin showed superior glycemic control in treatment-naive and resistant type 2 diabetics.

Store below 25°C (77°F)

Keep in a dry place, protected from light

Keep out of reach of children

Do not use after expiry date

FAQs – Amaryl (Glimepiride Tablets)
Q1: What is Amaryl used for?
A: Amaryl is used to manage type 2 diabetes mellitus in adults, either alone or in combination with other antidiabetic medications.

Q2: When is the best time to take Amaryl?
A: Take Amaryl once daily with breakfast or your first main meal to reduce the risk of hypoglycemia.

Q3: Can Amaryl cause weight gain?
A: Yes, weight gain is a common side effect of sulfonylureas like glimepiride.

Q4: Can Amaryl be combined with insulin?
A: Yes, in some cases where blood sugar control is inadequate with oral therapy alone, glimepiride may be combined with insulin.

Q5: Is Amaryl safe in pregnancy?
A: No, glimepiride is not recommended during pregnancy. Insulin is the preferred treatment for diabetes in pregnancy.

Q6: What should I do if I miss a dose?
A: Take the missed dose as soon as you remember. If it’s near your next scheduled dose, skip the missed one—never double up to compensate.
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