Glimepiride Metformin Tablets – Dual Oral Therapy for Type 2 Diabetes Mellitus
Buy Glimepiride Metformin Online – Combination Antidiabetic Medication for Effective Blood Sugar Control at EZ Chemist

What is Glimepiride Metformin used for?
Glimepiride Metformin is a combination antidiabetic medicine used to manage Type 2 Diabetes Mellitus in adults. It helps control blood sugar by combining glimepiride, a sulfonylurea that stimulates insulin release, and metformin, a biguanide that reduces liver glucose production and improves insulin sensitivity.

Product Name:
Glimepiride + Metformin Tablets

Active Ingredients:
Glimepiride

Metformin Hydrochloride (HCl)

Other Common or Brand Names:
Glucovance

Glycomet GP

Amaryl M

Glemiprex M

Glimet

GP-Met

Generic Glimepiride Metformin Tablets

Drug Classification:
Glimepiride: Sulfonylurea (Oral Hypoglycemic)

Metformin: Biguanide

ATC Code: A10BD02 (Combination)

Schedule: Prescription-Only Medicine (Rx)

Mechanism of Action (Mode of Action):
Glimepiride:
Acts by stimulating pancreatic beta cells to release insulin. It binds to ATP-sensitive potassium channels, enhancing glucose-dependent insulin secretion.

Metformin:
Primarily works by suppressing hepatic gluconeogenesis (glucose production in the liver), increasing insulin sensitivity in muscle tissues, and improving peripheral glucose uptake without causing hypoglycemia when used alone.

Together, the combination addresses both insulin resistance and impaired insulin secretion, providing a complementary glucose-lowering effect.

Indications and Uses:
Management of Type 2 Diabetes Mellitus (T2DM) in adults

When diet, exercise, and monotherapy with either glimepiride or metformin fail to control blood sugar

As initial therapy or as step-up therapy in progressive insulin resistance

Available Strengths & Forms:
Glimepiride 1 mg + Metformin 500 mg / 850 mg / 1000 mg

Glimepiride 2 mg + Metformin 500 mg / 850 mg / 1000 mg

Dosage Forms: Film-coated tablets, sustained release (SR), and immediate release (IR) forms available

Dosage & Administration:
General Dosage Guidelines:

Initial dose: 1 mg Glimepiride + 500 mg Metformin once daily with breakfast

Maintenance dose: Adjusted based on patient’s blood glucose levels

Maximum daily dose: Glimepiride 8 mg + Metformin 2000 mg per day

Important:

Tablets should be taken with food to reduce gastrointestinal side effects

Titration should be done cautiously to minimize the risk of hypoglycemia

Extended-release (XR/SR) forms should not be crushed or chewed

Prescribing & Monitoring Guidelines:
Monitor fasting blood glucose (FBG), postprandial glucose (PPG), and HbA1c every 3–6 months

Monitor renal function (serum creatinine, eGFR) before initiation and periodically thereafter

Monitor liver enzymes, and vitamin B12 levels in long-term metformin use

Safety Information, Warnings & Cautions:
Contraindications:

Type 1 Diabetes Mellitus

Diabetic ketoacidosis or metabolic acidosis

Severe renal impairment (eGFR <30 mL/min/1.73m²)

Hepatic failure

Hypersensitivity to sulfonylureas or metformin

Caution Required In:

Elderly patients (>65 years)

Those undergoing radiologic studies with iodinated contrast agents

Patients with heart failure, alcohol use disorder, or hypoglycemia risk

Side Effects (Based on Clinical Studies):
Common Adverse Effects:

Hypoglycemia (glimepiride-related, especially in elderly or malnourished)

Gastrointestinal upset (nausea, diarrhea, metallic taste from metformin)

Weight gain (minor, from sulfonylurea)

Headache, dizziness, fatigue

Rare but Serious Effects:

Lactic acidosis (metformin-induced, very rare but life-threatening)

Hepatotoxicity

Vitamin B12 deficiency (long-term metformin use)

Allergic skin reactions
Drug Interactions:
Increased hypoglycemia risk with: Insulin, beta-blockers, NSAIDs, alcohol

Reduced effectiveness with: Thiazides, corticosteroids, estrogens

Metformin interaction risk: Contrast dyes (withhold before and after imaging), cimetidine (reduced renal clearance)

ACE inhibitors & ARBs: May enhance hypoglycemic effect

Warfarin: May require monitoring of INR

Storage Instructions:
Store at below 25°C in a dry place, away from moisture and light

Keep out of reach of children

Do not use past expiry date printed on the label

FAQs – Glimepiride Metformin Tablets
Q1: Is Glimepiride Metformin safe for long-term use?
Yes. With regular monitoring of blood glucose, renal function, and vitamin B12 levels, it is safe and effective for chronic use.

Q2: Can I use Glimepiride Metformin for Type 1 Diabetes?
No. It is indicated only for Type 2 Diabetes Mellitus as it requires functioning beta cells in the pancreas.

Q3: Should I stop Glimepiride Metformin before surgery or radiologic tests?
Yes. Metformin should be withheld before major surgery or contrast scans, and resumed only after ensuring normal kidney function.

Q4: Will I gain weight with Glimepiride Metformin?
Mild weight gain is possible due to glimepiride. However, metformin often offsets this effect slightly.

Q5: Can I drink alcohol while on this medication?
Avoid excessive alcohol consumption, as it may increase the risk of lactic acidosis and hypoglycemia.