Treanda Injection – Bendamustine Hydrochloride | EZ Chemist Online Pharmacy
Generic Name: Bendamustine Hydrochloride
Brand Names: Treanda, Ribomustin, Levact
Drug Class: Alkylating Agent (nitrogen mustard derivative)
Form: Intravenous injection
Prescription Status: Prescription-only

What is Treanda Injection used for?
Treanda (Bendamustine) is a chemotherapy injection used to treat chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) after prior treatment. It works by disrupting DNA replication in cancer cells, leading to apoptosis.

What is Treanda Injection?
Treanda Injection contains Bendamustine Hydrochloride, a synthetic antineoplastic agent with alkylating and purine analog properties. It is used in the treatment of hematological malignancies such as chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphomas (NHL) that are unresponsive to rituximab-based therapies.

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Mode of Action:
Bendamustine acts through two primary mechanisms:

Alkylating effect: Causes DNA cross-linking, leading to DNA strand breaks and inhibition of replication.

Purine analog activity: Mimics purine bases, further disrupting DNA and RNA synthesis.

This dual mechanism results in programmed cancer cell death (apoptosis).

Recommended Dosage:

CLL: 100 mg/m² IV on Days 1 and 2 of a 28-day cycle, up to 6 cycles

NHL: 120 mg/m² IV on Days 1 and 2 of a 21-day cycle, up to 8 cycles

Route: Administered via intravenous infusion over 10 minutes.

Note: Dosing must be adjusted for renal, hepatic impairment, or hematologic toxicity. Always follow oncologist instructions.

Prescribing Information:
Administration: Dilute with 0.9% sodium chloride to 500 mL before IV infusion.

Monitoring: CBC with differential, liver and renal function tests before and during therapy.

Storage: Store in refrigerator at 2–8°C. Do not freeze.

Safety Information & Warnings:
Myelosuppression: Significant risk; monitor blood counts regularly.

Infections: May increase susceptibility to opportunistic infections.

Tumor Lysis Syndrome: Can occur in patients with high tumor burden.

Embryo-fetal toxicity: Contraindicated during pregnancy.

Secondary malignancies: Increased long-term risk of myelodysplastic syndrome and AML.

Common Side Effects:
Nausea, vomiting

Fatigue, fever

Anemia, neutropenia, thrombocytopenia

Rash, pruritus

Infections (pneumonia, herpes zoster)

Serious Side Effects:

Infusion reactions

Hepatotoxicity

Pulmonary toxicity

Tumor lysis syndrome

Drug Interactions:
CYP1A2 substrate drugs (e.g., fluvoxamine, ciprofloxacin) may interact with Bendamustine.

Increased risk of toxicity with immunosuppressants

Live vaccines should be avoided due to immunosuppression risk

Use caution with nephrotoxic agents
Warnings and Cautions:
Not recommended in severe hepatic impairment (bilirubin >3 mg/dL)

Avoid breastfeeding during and 1 week after treatment

Contraception is required during and 6 months post-treatment

Drug Classification:
ATC Code: L01AA09

Schedule: Rx only (prescription required)

Category: Antineoplastic, Alkylating Agent

Frequently Asked Questions (FAQs)
Q1. Is Treanda the same as Bendamustine?
Yes, Treanda is the brand name for bendamustine hydrochloride used in cancer treatment.

Q2. How quickly does Treanda work?
Clinical improvements can be seen within a few treatment cycles, but response may vary by cancer type and stage.

Q3. Can Treanda cause hair loss?
Hair loss is not a common side effect, though it may occur in some patients.

Q4. Is Treanda chemotherapy?
Yes, it is a chemotherapy drug used specifically for blood cancers like CLL and NHL.

Q5. Can Treanda be used with other chemotherapy drugs?
Yes, it may be combined with other agents such as rituximab depending on treatment protocol.