Buy Hemabate Injection (Carboprost Tromethamine) – Uterotonic for Postpartum Hemorrhage and Abortion Induction | EZ Chemist Online Pharmacy

Hemabate Injection contains carboprost tromethamine, a synthetic prostaglandin used to treat severe postpartum hemorrhage due to uterine atony and for medically indicated abortion. It stimulates uterine contractions and reduces bleeding by increasing uterine tone.

Comprehensive Product Description for Hemabate Injection
Generic Name: Carboprost Tromethamine
Brand Names: Hemabate, Prostavin
Drug Class: Prostaglandins – Uterotonic agents
Formulation: Injection (Intramuscular use)
Strength Available: 250 mcg/mL in 1 mL ampoule
Route of Administration: Intramuscular (IM) only
Prescription Required: Yes
Availability: Buy Hemabate Injection Online – EZ Chemist

Active Ingredient
Carboprost Tromethamine (15-methyl PGF2α)
A synthetic analogue of prostaglandin F2α with potent uterotonic activity. It induces contractions of uterine smooth muscle, helping control bleeding or induce abortion.

Other Popular and Common Names
PGF2 Alpha

Carboprost

Carboprost Injection

Hemabate Uterotonic

Carboprost Tromethamine 250 mcg

Mode of Action
Carboprost tromethamine acts as a prostaglandin F2α analogue, binding to prostaglandin receptors on uterine smooth muscle. This stimulates rhythmic uterine contractions, leading to:

Hemostasis (control of bleeding) in postpartum hemorrhage (PPH)

Expulsion of uterine contents in abortion procedures

Increased uterine tone and reduced uterine atony

Its oxytocic properties make it effective when other agents like oxytocin or ergometrine are insufficient.

Therapeutic Uses / Indications
FDA-Approved Uses:
Treatment of Postpartum Hemorrhage (PPH) due to uterine atony unresponsive to conventional methods (e.g., oxytocin)

Induction of abortion between 13–20 weeks of gestation for medically indicated termination

Off-Label Uses:
Intraoperative uterine atony control

Management of incomplete or missed abortion

Treatment of molar pregnancy evacuation complications

Dosage and Administration
For Postpartum Hemorrhage (PPH):

Initial Dose: 250 mcg IM

Repeat Dose: Every 15–90 minutes as needed

Maximum Dose: 2 mg total (8 doses)

For Abortion Induction (13–20 weeks gestation):

Initial Dose: 250 mcg IM

Repeat Dose: Every 1.5 to 3.5 hours

Maximum Dose: Not to exceed 12 mg total

Important Notes:

Administer only via deep intramuscular Injection

Not for intravenous use

Use in a hospital setting with resuscitation equipment available

Prescribing Information
Must be used under close supervision by qualified medical personnel

Reserved for life-threatening uterine bleeding or failure of first-line uterotonics

Continuous monitoring of uterine response and vital signs required

Emergency interventions must be available

Safety Information
Contraindications:
Hypersensitivity to prostaglandins

Active pelvic inflammatory disease

Severe cardiovascular disease (e.g., hypertension, cardiac arrhythmia)

Asthma or pulmonary disease

Hepatic or renal impairment

Glaucoma

Side Effects
Common Side Effects:
Nausea, vomiting, diarrhea

Flushing

Chills

Abdominal cramps

Fever

Serious Adverse Reactions:
Hypertension

Bronchospasm (especially in asthmatics)

Anaphylaxis

Seizures

Severe gastrointestinal bleeding

Cardiac arrhythmias

Warnings and Cautions
Risk of bronchospasm: Contraindicated in asthmatics

Monitor for hypertension, diarrhea, and uterine hypertonicity

Not to be used for elective abortion beyond 20 weeks

Avoid use with history of seizure disorders, glaucoma, or renal/hepatic compromise

Should only be used where emergency care is available

Drug Interactions
Oxytocin: May potentiate uterine effects – use sequentially, not concurrently

Ergometrine: Additive risk of hypertension

Beta-blockers: Increased risk of bronchospasm

NSAIDs: Potential interference with prostaglandin action

Magnesium sulfate: Monitor for hypotension or neuromuscular blockade

Drug Classification
Pharmacologic Class: Prostaglandin Analogue (PGF2α)

Therapeutic Class: Uterotonic Agent / Abortifacient

ATC Code: G02AD04

Regulatory Category: Prescription-only medication (Rx)

Frequently Asked Questions (FAQs)
What is Hemabate used for?
Hemabate is used to treat severe postpartum hemorrhage due to uterine atony and to induce abortion in the second trimester when medically indicated.

How does Hemabate Injection work?
It mimics prostaglandin F2α, causing the uterus to contract and reduce bleeding or expel uterine contents.

Can Hemabate be given intravenously?
No. Hemabate must only be given via intramuscular Injection to avoid serious cardiovascular complications.

What are the main side effects of Hemabate?
Common side effects include nausea, diarrhea, fever, and flushing. Serious effects like bronchospasm or hypertension may occur in sensitive individuals.

Is Hemabate safe in asthma patients?
No. Hemabate is contraindicated in asthma due to the risk of severe bronchospasm.

How long does it take for Hemabate to work?
Uterine response generally begins within 5 minutes of administration and peaks at around 30 minutes.