Comprehensive Product Description for Bystolic – EZ Chemist Online Pharmacy

What is Bystolic used for?
Bystolic (Nebivolol) is a cardioselective beta-blocker used primarily for the treatment of high blood pressure (hypertension). It lowers blood pressure by slowing the heart rate and relaxing blood vessels, reducing the risk of strokes, heart attacks, and kidney problems. Bystolic is known for its unique nitric oxide-mediated vasodilation property and is available at EZ Chemist with prescription support.

Product Name:
Bystolic Tablets

Active Ingredient:
Nebivolol Hydrochloride

Available Strengths:
Bystolic 2.5 mg

Bystolic 5 mg

Bystolic 10 mg

Bystolic 20 mg

Other Popular or Common Names:
Generic Name: Nebivolol

Brand Names (International): Bystolic, Nebilet, Nebivol, Nebicard

Therapeutic Class Names: Beta-1 selective adrenergic blocker with vasodilatory properties

Mode of Action:
Bystolic is a highly selective beta-1 adrenergic receptor blocker with additional vasodilating action via nitric oxide (NO) release. It reduces blood pressure through:

Decreased heart rate and myocardial contractility (cardioselective beta-blockade)

Peripheral vasodilation by enhancing endothelial nitric oxide release, improving vascular tone and reducing systemic vascular resistance.

This dual action leads to superior blood pressure control and improved arterial compliance without significantly affecting heart rate variability or insulin sensitivity.

Therapeutic Uses:
Bystolic is prescribed for:

Primary hypertension (mild to moderate)

Isolated systolic hypertension in elderly patients

Off-label uses:

Heart failure with preserved ejection fraction (HFpEF)

Anxiety-induced tachycardia

Migraine prophylaxis

Angina (under clinical discretion)

Dosage & Administration:
For Hypertension (Adults):
Initial dose: 5 mg once daily

Titration: May be increased at 2-week intervals up to a maximum of 40 mg once daily, depending on patient response and tolerability

For Elderly or Hepatic/Renal Impairment:
Start at 2.5 mg once daily

Administration Tips:
Take with or without food

Same time each day for best effect

Do not split or crush the tablets

Note: Always consult your healthcare provider for individualized dosing.

Prescribing Information:
Prescription required

Monitor blood pressure, heart rate, and renal function regularly

Adjust dose based on clinical response

Avoid abrupt discontinuation—taper gradually over 1–2 weeks

Drug Classification:
Therapeutic Class: Antihypertensive

Pharmacologic Class: Beta-1 selective adrenergic blocker (third-generation)

Schedule: Prescription-only medication (Rx)

Safety Information:
Contraindications:
Severe bradycardia (<60 bpm)

Heart block greater than first degree

Cardiogenic shock

Decompensated heart failure

Severe hepatic impairment

Hypersensitivity to nebivolol or any excipients

Warnings and Precautions:
Avoid sudden withdrawal – may worsen angina or cause MI in patients with CAD

Use cautiously in patients with reactive airway disease

Monitor glucose in diabetics—may mask signs of hypoglycemia

Caution in thyrotoxicosis – may mask tachycardia

May cause sexual dysfunction or fatigue

Not recommended in children (<18 years) due to insufficient safety data

Side Effects:
Common Side Effects:
Headache

Fatigue

Dizziness

Bradycardia

Diarrhea

Insomnia

Less Common / Serious Side Effects:
Dyspnea

Hypotension

Peripheral edema

Depression or mood changes

Rash or allergic reaction

Clinical Evidence: A randomized controlled trial published in Hypertension (2007) demonstrated that nebivolol significantly lowers blood pressure with fewer side effects compared to atenolol, and improves endothelial function due to nitric oxide–mediated vasodilation.

Drug Interactions:
Drug/Class Interaction Recommendation
Calcium channel blockers (verapamil/diltiazem) Additive bradycardia Monitor ECG and HR
Digitalis glycosides (digoxin) Enhanced bradycardia Monitor pulse
CYP2D6 inhibitors (paroxetine, fluoxetine) Increased nebivolol levels Dose adjustment may be needed
Insulin and antidiabetics May mask hypoglycemia symptoms Monitor glucose levels
NSAIDs Reduced antihypertensive effect Monitor BP

Frequently Asked Questions (FAQs)
Q1: Is Bystolic better than other beta-blockers?
A: Bystolic offers added vasodilation through nitric oxide release, potentially improving blood flow and reducing side effects such as fatigue and cold extremities commonly associated with traditional beta-blockers like atenolol or metoprolol.

Q2: Can I take Bystolic at night?
A: Yes, Bystolic can be taken at night, especially if it causes dizziness. The timing should be consistent.

Q3: Is Bystolic safe for diabetics?
A: Bystolic is considered metabolically neutral and may be safer than older beta-blockers for diabetic patients. However, blood sugar should still be monitored.

Q4: How long does Bystolic take to lower blood pressure?
A: Initial reduction is often seen within 1–2 weeks. Full effect may take up to 4 weeks of regular use.

Q5: What should I do if I miss a dose?
A: Take the missed dose as soon as remembered, unless it’s almost time for the next dose. Do not double dose.