Generic Arixtra Injection (Fondaparinux Sodium) – Anticoagulant for DVT & PE Prevention | Buy Online at EZ Chemist
Generic Arixtra (Fondaparinux Sodium) Injection – Anticoagulant for DVT, PE, and Surgery-Related Clot Prevention | Buy Online at EZ Chemist

What is Generic Arixtra Injection used for?
Generic Arixtra (Fondaparinux Sodium) is an anticoagulant Injection used to prevent and treat deep vein thrombosis (DVT) and pulmonary embolism (PE). It is also used post-surgery to prevent blood clots by inhibiting Factor Xa activity, thereby reducing thrombin formation.
Brand Name: Arixtra

Generic Name: Fondaparinux Sodium

Formulation: Prefilled subcutaneous Injection

Strengths Available: 2.5 mg/0.5 mL, 5 mg/0.4 mL, 7.5 mg/0.6 mL, 10 mg/0.8 mL

Administration Route: Subcutaneous (under the skin)

Drug Class: Selective Factor Xa Inhibitor / Anticoagulant
Prescription Status: Rx (prescription-only)
Fondaparinux Sodium

Other Common or Popular Names
Generic Arixtra

Fondaparinux Injection

Factor Xa Inhibitor Injection

DVT Prevention Injection

Fondaparinux Sodium Pre-filled Syringe
Fondaparinux is a synthetic pentasaccharide that binds selectively to antithrombin III, enhancing its ability to inhibit Factor Xa, a critical enzyme in the coagulation cascade. By inhibiting Factor Xa, fondaparinux prevents the formation of thrombin and thus the development of fibrin clots, without directly affecting platelet function.
Prevention of DVT (Deep Vein Thrombosis) following:

Hip fracture surgery

Knee or hip replacement

Abdominal surgery (in high-risk patients)

Treatment of acute DVT and PE (Pulmonary Embolism)

VTE prophylaxis in medically ill patients with restricted mobility

Off-label: Prevention of arterial thromboembolism (in select cases)
Indication Dosage Frequency Duration
DVT Prevention 2.5 mg SC once daily Start 6–8 hours post-op 5–9 days (or until fully ambulatory)
DVT/PE Treatment Weight-based:

<50 kg: 5 mg

50–100 kg: 7.5 mg

100 kg: 10 mg | Once daily SC | Minimum 5 days, until oral anticoagulation is stabilized

Route: Subcutaneous (abdomen, thigh)

Storage: Refrigerated at 2°C–8°C (do not freeze)

Injection Technique: Use as per nurse/doctor instructions; do not rub Injection site

Prescribing Information
Initiation: Based on clinical risk and surgical profile

Monitoring: Routine coagulation monitoring not needed (no aPTT/INR adjustment)

Transition: Overlap with warfarin may be necessary for long-term anticoagulation
Mild Injection site pain or redness

Nausea

Fever

Anemia

Serious Adverse Effects:
Bleeding (major or minor)

Thrombocytopenia (rare)

Spinal/Epidural Hematoma (especially in patients on neuraxial anesthesia)

Hypersensitivity reactions
Bleeding Risk: Avoid in patients with active bleeding, bleeding disorders, or uncontrolled hypertension

Renal Impairment: Contraindicated if CrCl <30 mL/min

Body Weight Considerations: Increased bleeding risk in patients <50 kg

Neuraxial Anesthesia: Risk of spinal hematoma; monitor closely

Pregnancy & Lactation: Use only if clearly needed; discuss with physician
Antithrombotic / Selective Factor Xa Inhibitor

Schedule H Drug (Rx required)
Drug Class Interaction
NSAIDs, Aspirin Increased risk of GI bleeding
Oral Anticoagulants (e.g., Warfarin, Apixaban) Cumulative anticoagulant effect
SSRIs (e.g., fluoxetine) Possible increased bleeding risk
Antiplatelet agents (e.g., Clopidogrel) Risk of hemorrhagic events

Use cautiously with any drug that affects hemostasis
PENTHIFRA Study: Showed Fondaparinux 2.5 mg was more effective than enoxaparin in preventing VTE after hip fracture surgery.

Frequently Asked Questions (FAQs)
Q1: Is Generic Arixtra the same as branded Arixtra?
Yes. Generic Fondaparinux contains the same active ingredient and works identically to the branded version but is more cost-effective.

Q2: Can I inject it at home?
Yes, if prescribed and properly trained, patients or caregivers can self-administer this Injection subcutaneously.

Q3: What should I do if I miss a dose?
Take the missed dose as soon as you remember unless it’s almost time for the next one. Do not double up on doses.

Q4: Is it safe during pregnancy?
It is categorized under Pregnancy Category B; consult a doctor before use in pregnancy or breastfeeding.

Q5: Can it be used with other blood thinners?
It should be used cautiously or avoided with other anticoagulants or antiplatelet agents unless supervised.

Q6: How long should I use Generic Arixtra?
Duration depends on the indication. For DVT prevention post-surgery, typically 5–9 days; for PE/DVT treatment, until INR is in therapeutic range with oral anticoagulants.