Advair Inhaler (Fluticasone Propionate and Salmeterol) – Comprehensive Product Description

Advair Inhaler is a combination medication containing fluticasone propionate (a corticosteroid) and salmeterol (a long-acting beta agonist). It is used to treat asthma and chronic obstructive pulmonary disease (COPD), improving lung function, reducing inflammation, and preventing bronchospasm and breathing difficulties.
Advair Inhaler
Generic Name: Fluticasone Propionate and Salmeterol Xinafoate
Other Common Names/Brands:

Seretide (International brand name)

AirDuo

Wixela Inhub

Fluticasone/Salmeterol Inhaler

Fluticasone Propionate: A potent synthetic corticosteroid that reduces inflammation in the airways.

Salmeterol Xinafoate: A long-acting beta-2 agonist (LABA) that relaxes bronchial smooth muscle, providing long-term bronchodilation.

Fluticasone binds to glucocorticoid receptors, inhibiting multiple types of inflammatory cells and decreasing cytokine production.

Salmeterol stimulates beta-2 adrenergic receptors in bronchial smooth muscle, causing muscle relaxation and bronchodilation for up to 12 hours.
This combination provides both anti-inflammatory effects and long-acting bronchodilation, addressing both causes of airway obstruction in asthma and COPD.

Advair is indicated for:

Maintenance treatment of asthma in patients aged ≥4 years

Chronic Obstructive Pulmonary Disease (COPD), including chronic bronchitis and/or emphysema

Reduction of exacerbations and improved symptom control in chronic respiratory diseases

Note: It is not indicated for acute asthma attacks.

GOAL Study: Patients using fluticasone/salmeterol achieved better asthma control than fluticasone alone.

TORCH Study: Demonstrated a significant reduction in COPD exacerbations and improvement in lung function.

FDA & EMA Approved for long-term control of asthma and COPD.

Available Strengths at EZ Chemist
100/50 mcg

250/50 mcg

500/50 mcg
Each strength is available as a Diskus (dry powder inhaler) or HFA Metered Dose Inhaler (MDI).

Shop Advair Inhaler Online at EZ Chemist

Dosage and Administration
Indication Dose Frequency
Asthma (Adults) 100/50 to 500/50 mcg Twice daily
COPD 250/50 mcg Twice daily
Pediatrics (≥4 yrs) 100/50 mcg Twice daily

Administration Tips:

Inhale 1 puff or 1 blister twice daily, approximately 12 hours apart.

Rinse mouth after each use to prevent oral thrush (candidiasis).

Use a spacer device with MDI if needed.

Prescription-only medicine (Rx)

Regular monitoring of lung function (FEV1), symptom control, and inhaler technique is advised.

Continue rescue inhaler (e.g., salbutamol) for sudden symptoms.

Well-tolerated with long-term use in both asthma and COPD patients

Not suitable as a rescue medication during acute bronchospasm

Should not be stopped abruptly without healthcare guidance

Side Effects
Common Side Effects:

Headache

Throat irritation

Hoarseness or voice changes

Cough

Nausea

Serious Side Effects:

Oral candidiasis (thrush)

Increased heart rate or palpitations

Adrenal suppression (with long-term use)

Paradoxical bronchospasm (rare)

Hypokalemia (low potassium) in high doses

Not for use in acute asthma attacks

May increase risk of asthma-related death if used as monotherapy (LABAs alone), but safe when used in combination with corticosteroid

Use with caution in patients with:

Cardiovascular disease

Diabetes mellitus

Hyperthyroidism

Seizure disorders

Avoid abrupt withdrawal of corticosteroid therapy

Beta-blockers: May antagonize salmeterol’s effect

Diuretics (e.g., furosemide): May enhance risk of hypokalemia

Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): Increase risk of systemic corticosteroid side effects

MAOIs, tricyclic antidepressants: May potentiate salmeterol’s cardiovascular effects

Therapeutic Class: Respiratory agents

Pharmacologic Class: Inhaled corticosteroid + Long-acting beta agonist (ICS + LABA)

Pregnancy Category: C

Schedule: Prescription only

FAQs about Advair Inhaler
Q: What is the difference between Advair Diskus and Advair HFA?
A: Diskus is a dry powder inhaler; HFA is a metered-dose inhaler. Both contain the same active ingredients but have different delivery mechanisms.

Q: Can Advair be used during pregnancy?
A: Only if clearly needed and prescribed. Risk-benefit must be assessed by a physician.

Q: How long should I take Advair?
A: It is a long-term maintenance medication. Duration is determined by your doctor based on symptom control and lung function.

Q: Can I stop using Advair once I feel better?
A: No. Stopping may lead to worsening symptoms. Always consult your doctor before stopping.

Q: Is Advair a rescue inhaler?
A: No. It is for maintenance therapy. Use a short-acting beta-agonist (like salbutamol/albuterol) for acute relief.
Buy Advair Inhaler online

Fluticasone and Salmeterol Inhaler India

Asthma maintenance inhaler EZ Chemist

Inhaled corticosteroid for asthma

Long-acting inhaler for COPD

Advair Diskus price in India

Buy Seretide inhaler

Chronic asthma treatment inhaler

Fluticasone salmeterol combo inhaler

EZ Chemist Advair HFA Diskus

Advair Inhaler is a clinically proven combination of fluticasone propionate and salmeterol that effectively manages chronic asthma and COPD symptoms. It improves lung function, reduces inflammation, and lowers the risk of exacerbations when used consistently. Ideal for long-term respiratory management, it is available at EZ Chemist Online Pharmacy in multiple strengths and delivery formats for convenience and personalized care.